Uptime software realized early on that many orchestration solutions could involve very expensive software suites and services. They chose to extend their product by plugging it into VMware's vCenter Orchestrator (vCO) to allow for automated remediation of issues discovered by their monitoring solution.
The following video provides an overview of up.time's capabilities:
UpTime's integration with vCO is not a bolt-on solution; they have the integration as a core feature of their product. Simply install their package file in your vCO server and tell UpTime how and where to connect.
Once you've done that, you can specify vCO workflows as remediation actions from their easy to use web interface. The result:
Follow them on Twitter: @uptimesoftware